Charles P. Rabolli ☕️
Charles P. Rabolli

MD Candidate & PhD

About Me

MD candidate and research scientist specializing in RNA biology, the epitranscriptome, and cardiovascular disease. My doctoral work (PhD, The Ohio State University, 2025) revealed how m6A RNA methylation shapes cardiac function, metabolism, and remodeling — using molecular biology, mouse models, nanopore sequencing, and multi-omics approaches.

I am currently completing my MD with core clinical rotations at OSU and conducting AI-driven digital pathology research at the AI4Path lab. My work bridges basic science, translational medicine, and innovation — from mechanistic discoveries in RNA biology to building diagnostic tools powered by machine learning.

I am passionate about entrepreneurship and thrive at the intersection of medicine, engineering, and technology, translating bold ideas into real-world impact.

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Interests
  • RNA Biology & Epitranscriptomics
  • Cardiovascular Research
  • Translational Medicine
  • Artificial Intelligence
  • Business/Entrepreneurship
Education
  • MD, Doctor of Medicine

    The Ohio State University

  • PhD Biomedical Engineering

    The Ohio State University

  • CORe — Credential of Readiness

    Harvard Business School Online

  • BSc Biomedical Engineering, Summa Cum Laude

    Rutgers University

🧬 My Research

My research focuses on the epitranscriptome — specifically how N6-methyladenosine (m6A) RNA methylation regulates gene expression in the heart. During my PhD at The Ohio State University, I used molecular biology, mouse models, nanopore sequencing, and multi-omics to reveal how m6A shapes cardiac function, metabolism, and remodeling in response to stress and disease.

I am currently completing my MD at OSU, where clinical training in internal medicine, surgery, and other specialties deepens my understanding of how basic discoveries translate to patient care. I am also working at the AI Lab for Pathology Research (AI4Path), developing AI foundation models for digital pathology to transform diagnostic workflows.

Please reach out to collaborate 👋

Featured Publications
Recent Publications
(2025). AIMP3 maintains cardiac homeostasis by regulating the editing activity of methionyl-tRNA synthetase. Nature Cardiovascular Research, 4(7), pp. 876–890.
(2025). The cardiac METTL3/m6A pathway regulates the systemic response to Western diet. JCI Insight, 10(11), pp. e188414.
(2025). The m6A-binding protein YTHDF3 modulates the cardiac response to stress. RNA, 31(7), pp. 923–932.
(2024). Cardiac cryptographers: cracking the code of the epitranscriptome. European Heart Journal, 45(23), pp. 2034–2036.
(2024). CITED4 gene therapy protects against maladaptive cardiac remodeling after ischemia/reperfusion injury in mice. Molecular Therapy: The Journal of the American Society of Gene Therapy, 32(10), pp. 3683–3694.
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