Charles Rabolli

AI Foundation Models for Digital Pathology

Mon, 01 Sep 2025 00:00:00 +0000

As part of the AI Lab for Pathology Research (AI4Path) at The Ohio State University, I am contributing to the development of next-generation AI foundation models for computational pathology. This work involves:

Training large-scale vision foundation models on whole-slide histology images
Curating and annotating colorectal carcinoma slides to generate high-quality training data
Applying deep learning to enable scalable, intelligent interpretation of digital pathology images
Bridging molecular biology expertise with machine learning to enhance diagnostic accuracy

This research sits at the intersection of medicine, engineering, and AI — translating cutting-edge machine learning into real-world diagnostic tools.

Joined AI4Path Lab — AI for Pathology Research at OSU

Mon, 01 Sep 2025 00:00:00 +0000

Excited to join the AI Lab for Pathology Research (AI4Path) at The Ohio State University. In this role I am developing next-generation AI foundation models for pathology, leveraging large-scale histology datasets to transform diagnostic workflows. I am also curating and annotating colorectal carcinoma slides to generate high-quality training data for scalable, intelligent interpretation of digital pathology images.

New Paper: AIMP3 in Cardiac Homeostasis — Nature Cardiovascular Research

Tue, 01 Jul 2025 00:00:00 +0000

Proud to share a new paper in Nature Cardiovascular Research! “AIMP3 maintains cardiac homeostasis by regulating the editing activity of methionyl-tRNA synthetase” — uncovering a novel mechanism by which aminoacyl-tRNA synthesis quality control shapes cardiac function. Read it on PubMed.

New Paper: YTHDF3 Modulates Cardiac Response to Stress — RNA Journal

Sun, 01 Jun 2025 00:00:00 +0000

New paper published in RNA! “The m6A-binding protein YTHDF3 modulates the cardiac response to stress” — establishing YTHDF3 as a key regulator of cardiac remodeling under stress conditions. Read it on PubMed.

PhD Completed — Biomedical Engineering, The Ohio State University

Thu, 01 May 2025 00:00:00 +0000

Thrilled to share that I have successfully completed my PhD in Biomedical Engineering at The Ohio State University as part of the Medical Scientist Training Program (MSTP). My thesis, RNA Modifications (Epitranscriptome) in the maintenance of cardiac homeostasis, explored how m6A RNA methylation shapes cardiac function, metabolism, and remodeling — using molecular biology, mouse models, nanopore sequencing, and multi-omics approaches. Supervised by Prof. Federica Accornero.

New Paper: Cardiac METTL3/m6A Pathway and Systemic Response to Western Diet — JCI Insight

Tue, 01 Apr 2025 00:00:00 +0000

New paper out in JCI Insight! “The cardiac METTL3/m6A pathway regulates the systemic response to Western diet” — a study revealing how m6A RNA methylation in the heart shapes systemic metabolic function. Read it on PubMed.

AIMP3 maintains cardiac homeostasis by regulating the editing activity of methionyl-tRNA synthetase

Wed, 01 Jan 2025 00:00:00 +0000

The cardiac METTL3/m6A pathway regulates the systemic response to Western diet

Wed, 01 Jan 2025 00:00:00 +0000

The m6A-binding protein YTHDF3 modulates the cardiac response to stress

Wed, 01 Jan 2025 00:00:00 +0000

Projects

Sun, 19 May 2024 00:00:00 +0000

Oral Presentation — American College of Cardiology Scientific Sessions 2024

Sat, 06 Apr 2024 00:00:00 +0000

Presented oral research on the cardiac METTL3/m6A pathway and its regulation of systemic metabolic response to Western diet at the American College of Cardiology Scientific Sessions 2024 in Atlanta, GA.

Cardiac cryptographers: cracking the code of the epitranscriptome